Endothelial dysfunction as a potential contributor in diabetic nephropathy
نویسندگان
چکیده
منابع مشابه
A breakthrough in diabetic nephropathy: the role of endothelial dysfunction.
Kanetsuna et al. [1] have published an important paper in the American Journal of Pathology, reporting that renal lesions resembling human diabetic nephropathy can be induced in mice made diabetic (with streptozotocin) which genetically lack endothelial nitric oxide synthase (eNOS). eNOS is a key enzyme in endothelial cells that produces nitric oxide (NO). In turn, NO has multiple functions in ...
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BACKGROUND Activation of the renin-angiotensin-aldosterone system (RAAS) is an important mediator of diabetic nephropathy. Urinary angiotensinogen, a novel biomarker of the intrarenal RAAS, is associated with progressive kidney injury. In this study, the authors investigated the determinants of urinary angiotensinogen and its associations with staging of diabetic nephropathy. METHODS Random u...
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The rising incidence and prevalence of chronic kidney disease (CKD) (glomerular filtration rate ,60 mL/min per 1.73 m) is a major public health concern (U.S. Renal Data System 2010, http://www.usrds.org). Hypertension is the second leading cause of end-stage renal disease (ESRD) in the U.S. and is also a major contributor to diabetic renal disease, which is the leading cause of CKD and ESRD (U....
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ژورنال
عنوان ژورنال: Nature Reviews Nephrology
سال: 2010
ISSN: 1759-5061,1759-507X
DOI: 10.1038/nrneph.2010.152